Nanoparticles in the Lung

Nanoparticles in the Lung

Environmental Exposure and Drug Delivery

Tsuda, Akira; Gehr, Peter

Taylor & Francis Ltd

03/2021

404

Mole

Inglês

9781138749207

15 a 20 dias

453

Descrição não disponível.
Introduction. Deposition. Interaction with the Lung Surface. Role of the Biomolecule Corona in Nanoparticle Fate and Behavior. Interaction with Alveolar Lining Fluid. Interaction with Lung Macrophages. Interactions with Alveolar Epithelium. Mechanistic Aspects of Cellular Uptake. Cellular Uptake and Intracellular Trafficking. Translocation across the Air-Blood Tissue Barrier. The Pulmonary Lymphatic System. Translocation and Accumulation in the Body. Practical Considerations for Drug Delivery to the Respiratory Tract. Drug and Gene Delivery in the Lungs. Bio-Nanocapsules: Novel Drug Delivery. Physicochemical, Colloidal, and Transport Properties. Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore. Potential for Nose-to-Brain Delivery of Drugs. The Developing Lungs. Nanotoxicology. Summary.
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Clathrin Heavy Chains;Oxidative Stress Paradigm;Airway/alveolar surface;Air Blood Barrier;Crossing epithelial cells - interaction between NPs and alveolar epithelium;Biokinetics Studies;Translocation;Protein Corona;Nanoparticle drug delivery to respiratory tract;Dose Metrics;Special issues about nanoparticles;Alveolar Epithelium;Developing Lungs;Np Translocation;Nose-to-Brain Drug Delivery;Np Uptake;In Vitro Nanotoxicology;Ultrane Particles;Nanotoxicology;Clathrin Mediated Endocytosis;Dosimetry;Bronchoalveolar Lavage Uid;Transport Properties;Pa Rti;Colloidal Properties;Intratracheal Instillation;Physicochemical Properties;Secondary Organs;Novel Drug Delivery;Major Clearance Mechanisms;Bio-Nanocapsules;Cell Culture;Gene Delivery in Lungs;PLA Peg NPs;Drug Delivery in Lungs;DDS Nanocarriers;Respiratory Tract;Peg Shell;Respiratory Drug Delivery;Lung Draining Lymph Nodes;Pulmonary Lymphatic System;ENM Suspension;Air-Blood Tissue Barrier;pDNA Polyplex;Intracellular Trafficking;Alveolar Macrophage Clearance;Cellular Uptake;Olfactory Epithelium;Lung Macrophages;Alveolar Lining Fluid;Biomolecule Corona;Lung Surface;Nanoparticle Accumulation;Nanoparticle Interaction;Nanoparticle Behavior;Nanoparticles in Lungs